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DiLab® Bibliography

Contact us to request a copy of any of the following publications or posters.

Published papers

Manual versus automated blood sampling: impact of repeated blood sampling on stress parameters and behavior in male NMRI mice
A. Charlotte Teilmann, Otto Kallioski, Dorte B Sorensen, Jann Hau and Klas S P Abelson
Department of Experimental Medicine, University of Copenhagen, Denmark
Lab Animal published online 23 June 2014

The Effect of Automated Blood Sampling on Corticosterone Levels, Body Weight and Daily Food Intake in Permanently Catheterized Male BALB/c Mice
A. Teilmann, K. Rosenmaj Jacobsen, O. Kallioski, A. Kornerup Hansen, J. Hau, K. Abelson
Department of Experimental Medicine, University of Copenhagen, Denmark
Department of Veterinary Disease Biology, Section of Biomedicine, University of Copenhagen, Denmark
in vivo 26: 577-582 (2012)

Utilization of dried blood spots within drug discovery: modification of a standard DiLab® AccuSampler® to facilitate automatic dried blood spot sampling.
Clark GT, Giddens G, Burrows L, Strand C.
Lab Anim. 2011 Apr;45(2):124-6. Epub 2011 Feb 25.

Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats
Silvia Bison, Maria Razzoli, Roberto Arban, Francesca Michielin, Simone Bertani, Lucia Carboni
GlaxoSmithKline S.p.A., Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy
European Journal of Pharmacology 661 (2011) 49–56

Circadian Profile of Peripheral Hormone Levels in Sprague-Dawley Rats in Common Marmosets (Callithrix jacchus).
Simone Bertani, Lucia Carboni, Ana Criado, Francesca Michielin, Laura Mangiarini, Elena Vicentini.
GlaxoSmithKline Medicines Research Centre, Verona - Italy
In Vivo 24:827-836(2010)

Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain.
Bender G, Florian JA Jr, Bramwell S, Field MJ, Tan KK, Marshall S, DeJongh J, Bies RR, Danhof M.
J Pharmacol Exp Ther. 2010 Aug;334(2):599-608. Epub 2010 May 5.

AccuSampler Standard - Automated Blood Sampling for ADME studies
Strand C and Dong C.
Asian Journal of Pharmacodynamics and Pharmacokinetics 2009; 9(2):156-158

Population pharmacokinetic model of the pregabalin-sildenafil interaction in rats: application of simulation to preclinical PK-PD study design.
Bender G, Gosset J, Florian J, Tan K, Field M, Marshall S, DeJongh J, Bies R, Danhof M.
Pharm Res. 2009 Oct;26(10):2259-69. Epub 2009 Aug 11.

Automated blood sampling and the 3Rs
A. Holmberg and R. Pelletier
NC3Rs #16, April 2009 (Available at

Validation of the Use of Nonnaive Surgically Catheterized Rats for Pharmacokinetics Studies;
Sujal V Deshmukh et al., Journal of the American Association for Laboratory Animal Science, November 2008

Corticosterone Concentrations in Blood and Excretion in Faeces after ACTH Administration in Male Sprague- Dawley Rats;
H. Siswanto et al., in vivo 22: 435-440 2008

Direct injection of whole blood for liquid chromatography/tandem mass spectrometry analysis to support single-rodent pharmacokinetic studies; Benno A. Ingelse et. al., Wiley InterScience, 2008

Effect of Subcutaneous Injection and Oral Voluntary Ingestion of Buprenorphine on Post-Operative Serum
Corticosterone Levels in Male Rats;
R. Goldkuhl et. al., Eur Surg Res, January, 2008

Sex Difference in Link between Interleukin-6 and Stress;
R. Jankord et al., Endocrinology, May 2007

Drug Distribution in Spinal Cord during Administration with Spinal Loop Dialysis Probes in Anaesthetized Rats;
Maria Uustalu and Klas S. P. Abelson, Nordic Pharm. Soc.. Basic & Clin. Pharm. & Tox.2007

Pharmacokinetic/Pharmacodynamic Feedback Modelling of the Functional Corticosterone Response in Rats after Acute Treatment with Escitalopram;
C. Bundgaard et. al, Nordic Pharm. Soc. Basic & Clin. Pharm. & Tox, 2007

The impact of the AccuSampler;
Lynn Griffiths, Journal of the Inst. Of Animal Technology, Vol. 5 No.2 Aug. 2006

An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of
serotonergic agents; C. Bundgaard et. al, Journal of Pharm.and Tox. Methods, 2006

Effect of Repeated Confined Single Housing of Young Pigs on Faecal Excretion of Cortisol and IgA;
F. Royo et al., Scand. J. Lab. Anim. Sci. No. 1. 2005.

Quantitative Measurement of Changes in…;
Best et. al, Nordic Pharm. Soc. Basic & Clin. Pharm. & Tox., 2005

Comparative Analysis of ACTH and Corticosterone Sampling Methods in Rats;
T P. Vahl et. al, AJP – Endocrin. and Met., June 14, 2005

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic;
M. Leist et. al, Science, Vol 305, 2004, July

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats;
F Royo et al., Journal of Endocrinology, 2004

Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats;
E. Eriksson et al., The Physiological Soc., 2004

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo;
S. Erbayraktar et. al, PNAS, May 2003

Automatic in vivo Blood Sampling and Direct Analysis on Whole Blood;
Sonne K.*, Andersen H. J. et. al, Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2-6, 2002

Posters & Presentations

Utility of Dry Blood Spot (DBS) Bioanalysis in Rat Cross-Over Pharmacokinetic (PK) Studies
Manuel Cajina, Megan E Nattini and Gamini Chandrasena
Bioanalysis & Physiology, Lundbeck Research USA, Paramus, NJ, USA

Combined Automatic Blood Sampling and Food Intake Measurements in Rats
Kent Pedersen, Diabetes Pharmacology - Type 2 Diabetes, Diabetes Research Unit, Novo Nordisk A/S

Accusampler® µ as a powerful tool for studying mechanisms of insulin resistance in conscious mice
Mikkel Schrøder Jørgensen,
Department of Diabetes and Obesity Pharmacology, Novo Nordisk A/S

Automated Pharmacokinetic Sampling in the Rat by both Dried Blood Spot and Liquid Blood Methods
David Paterson, Sylvia Vekich, Robert Hunter, Zhongzhou Shen and Ravi Rahavendran, La Jolla, CA, USA

Accusampler® platform application contributes to the 3R’s principle: example from a preclinical study.
Simone Bertani, Claudio Righetti, Maria Razzoli, Roberto Arban and Elena Vicentini.
GlaxoSmithKline Medicines Research Centre, Verona - Italy

Coupling of Accusampler® technology and ICV cannulation in male rats: stress level evaluation during a pilot study
Simone Bertani, Elena Arzenton and Elena Vicentini.
GlaxoSmithKline Medicines Research Centre, Verona - Italy

Application of Automated Blood Sampling in Cross-Over Pharmacokinetic (PK) Studies: Increased Throughput Verses Reducing Systemic Infection Risk in Animals;
A.P. Gunatilaka et al.

Automated Blood Sampling for Pharmacokinetic Studies: Lessons learned in setting up an AccuSampler® lab for multiple users:
Tracey H. Clark

Automated blood sampling using a novel micro sampling technique;
E.N Spoelstra, H A Hansson et al.

Comparison of different experimental pharmacokinetic designs in rats. Use of an automated blood sampling device – the AccuSampler®; A. Grynberg

Enhanced corticosterone secretion induced by RU38486 during the circadian rhythm in cannulated rats;
S. Bertani and J. Rimland

Further Refinements in the Jugular Vein Cannulated Rat Model;
Ruth Storer et al.

Improvements in order to avoid systemic inflammation in AccuSampler rats;
Dorrit Bjerg Larsen et al.

Influence of anaesthesia on in vivo pharmacokinetics of dexamethasone and fl uconazole; A comparative study of administration site and sampling methods;
M. Sababi et al.

Investigation of sample dilution on Accusampler Standard used for pharmacokinetic studies;
Kent Pedersen et al.

Long term patency of vascular catheters in rats;
Mikkel S. Jørgensen and Hanne B. Jensen Holm

Novelty stress: dynamics and correlations in the behavioral and physiological stress response of rats;
Wieteke Beerling et al.

Preliminary Results from Automated Dual sampling with the Accusampler®;
Pascale M. Jacques

Prise de sang automatique en utilisant une nouvelle technique d’échantillonnage micronisée ;
E.N Spoelstra, H A Hansson et al. FRENCH

Serial blood sampling in hamsters with AccuSampler® Standard system;
Britt-Marie Fihn and Cecilia Wikell

Significant improvement of oral bioavailability of a poorly soluble compound;
Jeffry Grunkemeyer

Simulations to guide mechanism based PK-PD modeling of a synergistic interaction in an animal model of neuropathic pain;
Gregor Bender et al.

Simultaneous Microdialysis-BloodSampling Approach for PK/PD Evaluation of Citalopram in Rats;
Christoffer Bundgaard and MartinJørgensen

The effect of porcine ghrelin on growth hormone release and food intake in unstressed freely moving Göttingen minipigs using an accusampler system;
Pia von Voss et al.

The impact of the AccuSampler®;
Lynn Griffiths

Use of automated blood sampling in the light of Reduction and Refinement;
Matteo Sartori and Simone Bertani

Using automated blood sampling to eliminate stress-related interferences in rat prolaction studies;
Jianhua Liu et al.

Utilization of an automated blood sampling device for rat pharmacokinetic studies with direct bioanalysis by nano-esi-ms/ms from a silicon chip;
Marc Lastelle et al.

Non-peer published papers

Arterial Blood Pressure Measurement in Rats;
Ian Bunn and Kai Blumbach, RCC Ltd Researcher No. 20, Nov, 2004

Continuous Infusion Toxicity Testing in Rats;
Ian Bunn and Kai Blumbach, RCC Ltd Researcher no. 23, April 2006

GLP Validation of Continuous Intravenous Infusion Studies;
Ian Bunn and Kai Blumbach, RCC Ltd researcher No. 24, Nov, 2006